Benzocaine Powder Chemical



Benzocaine Powder Chemical

Benzocaine Powder Chemical

A water-insoluble ester-type local anesthetic agent that is mainly useful for topical application. The onset of action is rapid (<1 minute), and the effective duration is 5 to 10 minutes. Benzocaine is also most commonly available as a 20% aerosol spray that is easily applied to the oropharyngeal mucosa. The limiting factor in benzocaine use is the potential development of clinically significant methemoglobinemia. In some patients, this can occur with as little as 1 to 2 seconds of spraying. The risk increases by almost 20-fold when expose benzocaine repeated within 1 week.

Although most patients tolerate benzocaine airway topicalization without any adverse effects, it is not possible to identify in advance those patients who are at risk for significant methemoglobinemia. In addition, some have advocated for the cessation of benzocaine use across the board. Symptoms of early methemoglobinemia toxicity noticed with methemoglobin levels of 5% and include cyanosis, tachycardia, and tachypnea. As levels increase to 20% to 30%, patients may develop chest pain, ischemic changes on ECG, hypotension, altered mental status, syncope, or coma. The most severe cases have led to neurologic hypoxic injury, myocardial infarction, and death. Should symptomatic methemoglobin occur, treatment is with methylene blue 1 to 2 mg/kg IV given over 5 minutes.110,111



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