AICAR Powder Chemical

$40.00

AICAR Powder Chemical

AICAR Powder Chemical

Also known as ZMP is an analog of AMP,  is Cell-permeable, allosteric activator of AMP-activated protein kinase (AMPK). It is capable of stimulating AMP-dependent protein kinase activity(AMPK),  augments proliferation, differentiation and mineralization of osteoblastic MC3T3-EI cells. And also attenuates psychosine-induced expression of proinflammatory cytokines and iNOS in astrocytes.

AICAR powder is an intermediate in the generation of inosine monophosphate. Clinically used to treat and protect against cardiac ischemic injury, it can enter cardiac cells to inhibit adenosine kinase and adenosine deaminase. It enhances the rate of nucleotide re-synthesis increasing adenosine generation from adenosine monophosphate only during conditions of myocardial ischemia. AICAR powder increases glucose uptake by inducing translocation of GLUT4 and/or by activating the p38 MAPK pathway. Currently, the drug has also been shown as a potential treatment for diabetes by increasing the metabolic activity of tissues by changing the physical composition of muscle.

AICAR is a purine precursor with antineoplastic activity. It is important in treatment of metabolic diseases such as type 2 diabetes as well as possible treatment of various cancer types.

It also enhances the rate of nucleotide re-synthesis increasing adenosine generation from adenosine monophosphate only during conditions of myocardial ischemia.

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