4-ACO-DMT Research Chemical



4-ACO-DMT Research Chemical

4-ACO-DMT Research Chemical

Also known as psilacetin is a semi-synthetic tryptamine closely related to the “magic mushroom” molecules psilocin and psilocybin. Like psilocybin, it appears to be metabolized by the body into psilocin.

Most people buy psilacetin as a brown or off-white powder mixed with water just prior to dosing. But it’s also available in pills, tablets, capsules, and gel tabs among other preparations.

While some find the effects indistinguishable from psilocybin mushrooms, others say it’s more like DMT. The difference may be dose-dependent. But mystical-type experiences are common, as are philosophical insights and a sense of empathic well-being.

4-AcO-DMT was first synthesized by Albert Hofmann (who discovered LSD) and his colleague Franz Troxler at Sandoz laboratories in Switzerland. However patented by the company, along with a number of other indole esters, in 1963. But it wasn’t until the 1990s that we first saw 4-AcO-DMT for sale alongside various “research chemicals” and “designer drugs.”


Nowadays, 4-AcO-DMT is the most popular of the synthetic/semi-synthetic tryptamines—although the use of these substances remains limited. For instance, while only 81  (3.55%) of the 2,282 US respondents to the 2013 Global Drug Survey reported ever having tried 4-AcO-DMT, substantially fewer people had ever tried 4-HO-DiPT (22 or 0.96%), 4-HO-MiPT (20 or 0.88%), or even the relatively well known 5-MeO-DMT (72 or 3.16%). The 2017 National Survey on Drug Use and Health, meanwhile, found that of 56,276 respondents, only three (0.01%) had ever used 4-AcO-DMT


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