25B-NBOMe Research Chemical
25B-NBOMe Research Chemical (also known as Cimbi-36 and 2C-B-NBOMe) is novel synthetic psychedelic substance of the phenethylamine chemical class. It produces an array of visually-dominant and stimulating psychedelic effects when administered.
The name 25B-NBOMe, which short-hand for 2C-B-NBOMe, is a derivative of the phenethylamine psychedelic 2C-B. It was discovered in 2004 by Ralf Heim at the Free University of Berlin. Also acts as a potent partial agonist for the 5-HT2A receptor. It has been used in clinical trials with an evaluation dose for safety consideration to humans of only 1 microgram. Such a dose was determined to be only 1/300th the dose expected to be hallucinogenic to humans. And that recreational use would greatly exceed doses determined to be safe to humans.
Anecdotal reports from users suggest 25B-NBOMe to be an active hallucinogen at a dose of as little as 250–500 µg. Thus making it a similar potency to other phenethylamine derived hallucinogens such as Bromo-DragonFLY. It is worth noting that compounds of the NBOMe class are not orally active and should therefore be taken sublingually by placing the substance into one’s mouth and allowing it to slowly absorb over a period of 15-30 minutes.
This substance had no history of human use before being sold online as a designer drug in 2010. Extremely little is known about the pharmacological properties, metabolism, and toxicity of 25B-NBOMe in humans, and numerous members of the 25x-NBOMe series have been associated with hospitalizations and deaths. Along with its highly sensitive dose-response and unpredictable effects, many reports also suggest that this substance may be overly difficult to use safely. Therefore it is highly advised to approach this poorly understood, potentially deadly psychedelic substance with the proper amount of precaution and harm reduction practices if choosing to use it.