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Also known as the endocannabinoid system in cells that alter neurotransmitter release in the brain. Ligands for these receptor proteins include the endocannabinoids produced naturally in the body by animals; phytocannabinoids, found in cannabis and some other plants; and synthetic cannabinoids, manufactured artificially. The most notable cannabinoid – the phytocannabinoid tetrahydrocannabinol (THC), the primary psychoactive compound in cannabis – (CBD)  another major constituent of the plant. In addition, at least 113 different cannabinoids isolated from cannabis, exhibits varied effects.

Cannabinoids have an effect on the user by interacting with specific receptors, placed among totally different components of the central system.